SUYAK TO'QIMALARINING TABIIY REGULYATORLARI. SURUNKALI UYQU BUZILISHI NATIJASIDA MELATONIN GORMONINING O’ZGARISHI
Keywords:
suyak to'qimalari, tabiiy regulyatorlar, melatonin, uyqu buzilishi, osteoblast, suyak metabolizmi, endokrin tizim, osteoporozAbstract
Suyak to'qimalarining funksiyasi va ularning barqarorligi nafaqat mexanik jihatdan, balki biologik jihatdan ham murakkab jarayonlarga bog'liq. So'nggi tadqiqotlar suyak metabolizmini boshqaruvchi ko'plab tabiiy regulyatorlar — jumladan, sitokinlar, osteokine, leptin, serotoning ta'siri — mavjudligini ko'rsatadi. Bularning ahamiyati alohida, chunki uyqu fazasi, xususan melatonin gormonining sekretsiyasi ham suyak yangilanishiga bevosita ta'sir qiladi. Surunkali uyqu buzilishi esa melatonin darajasining pasayishiga olib keladi, bu esa osteoblastlarning faolligini kamaytirib, suyak shakllanishini sekinlatadi hamda osteoporoz kabi kasalliklarning rivojlanish ehtimolini oshiradi. Ushbu maqolada suyak to'qimalarini boshqaruvchi asosiy tabiiy regulyatorlar tahlil qilinadi hamda surunkali uyqu buzilishi orqali melatoninning kamayishi natijasida suyak metabolizmining qanday buzilishi muhokama etiladi. Ilmiy ma'lumotlar asosida melatonin faqat uyquga emas, balki skelet tizimining sog'lig'i uchun ham muhim ekanligi tasdiqlanadi.
References
Cutando A, Gómez-Moreno G, Arana C, Acuña-Castroviejo D, Reiter RJ. Melatonin: potential functions in the oral cavity. J Periodontol. 2007 Jun;78(6):1094-102. doi: 10.1902/jop.2007.060396.
Li T, Jiang S, Lu C, Yang W, Yang Z, Hu W, Xin Z, Yang Y. Melatonin: Another avenue for treating osteoporosis? J Pineal Res. 2019 Mar;66(2):e12548. doi: 10.1111/jpi.12548.
López-Martínez F., Olivares Ponce P.N., Guerra Rodríguez M., Martínez Pedraza R. Melatonin: Bone metabolism in oral cavity. Int. J. Dent. 2012;2012:628406. doi: 10.1155/2012/628406.
Nakade O., Koyama H., Ariji H., Yajima A., Kaku T. Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro. J. Pineal Res. 1999;27:106–110. doi: 10.1111/j.1600-079X.1999.tb00603.x.
Witt-Enderby PA, Radio NM, Doctor JS, Davis VL. Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy. J Pineal Res. 2006 Nov;41(4):297-305. doi: 10.1111/j.1600-079X.2006.00369.x.
